abstract：:The acyclic analogue of guanosine acyclovir (ACV) constitutes the first-line drug for the treatment of herpes simplex virus (HSV) infections. ACV activation requires primophosphorylation by virus-encoded HSV thymidine kinase (TK). In 95% of cases, HSV resistance to ACV is associated with mutations located in TK. The a...

journal_title：Antiviral research

authors： Burrel S,Bonnafous P,Hubacek P,Agut H,Boutolleau D

更新日期：2012-12-01 00:00:00

abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...

journal_title：Antiviral research

authors： De Leo A,Arena G,Lacanna E,Oliviero G,Colavita F,Mattia E

更新日期：2012-11-01 00:00:00

abstract：:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the...

journal_title：Antiviral research

authors： Noble CG,Shi PY

更新日期：2012-11-01 00:00:00

abstract：:Approximately 170 million people worldwide are chronic carriers of Hepatitis C virus (HCV). To date, there is no prophylactic vaccine available against HCV. The standard-of-care therapy for HCV infection involves a combination of pegylated interferon-α and ribavirin. This therapy, which is commonly associated with sid...

journal_title：Antiviral research

authors： Ip PP,Nijman HW,Wilschut J,Daemen T

更新日期：2012-10-01 00:00:00

abstract：:EV71 is a major causative agent of hand, foot and mouth disease (HFMD) and is responsible for large outbreaks in various Asian Pacific countries. In the present study, we generated the recombinant baculovirus (Bac-VP1) encoding VP1 in a novel expression cassette. The transmembrane domain of hemagglutinin of the H3N2 i...

journal_title：Antiviral research

authors： Premanand B,Kiener TK,Meng T,Tan YR,Jia Q,Chow VT,Kwang J

更新日期：2012-09-01 00:00:00

abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...

journal_title：Antiviral research

authors： Rockx B,Winegar R,Freiberg AN

更新日期：2012-08-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) remain prevalent even with widespread use of combination antiretroviral therapy (ART), suggesting a potential role for co-morbidities in neurologic decline. Indeed, it is well established that ART drugs, particularly HIV protease inhibitors, can induce hyperlipidemia, lip...

journal_title：Antiviral research

authors： Gupta S,Knight AG,Losso BY,Ingram DK,Keller JN,Bruce-Keller AJ

更新日期：2012-07-01 00:00:00

abstract：:Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a gro...

journal_title：Antiviral research

authors： Chen X,Qiao H,Liu T,Yang Z,Xu L,Xu Y,Ge HM,Tan RX,Li E

更新日期：2012-07-01 00:00:00

abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

journal_title：Antiviral research

authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

更新日期：2012-06-01 00:00:00

abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...

journal_title：Antiviral research

authors： Prichard MN,Kern ER

更新日期：2012-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) translation is mediated by a highly conserved internal ribosome entry site (IRES), mainly located at the 5'untranslatable region (5'UTR) of the viral genome. Viral protein synthesis clearly differs from that used by most cellular mRNAs, rendering the IRES an attractive target for novel antivira...

journal_title：Antiviral research

authors： Romero-López C,Berzal-Herranz B,Gómez J,Berzal-Herranz A

更新日期：2012-05-01 00:00:00

abstract：:Japanese encephalitis virus (JEV) infection is a major cause of acute viral encephalitis both in humans and animals. The domain III of virus envelope protein (EDIII) plays important roles in interacting with host cell receptors to facilitate virus entry. In this study, recombinant JEV EDIII was expressed and purified....

journal_title：Antiviral research

authors： Li C,Zhang LY,Sun MX,Li PP,Huang L,Wei JC,Yao YL,Isahg H,Chen PY,Mao X

更新日期：2012-05-01 00:00:00

abstract：:Yellow fever virus (YFV), a member of the genus Flavivirus, is a mosquito-borne virus found in tropical regions of Africa and South America that causes severe hepatic disease and death in humans. Despite the availability of effective vaccines, YFV is responsible for an estimated 200,000 cases and 30,000 deaths annuall...

journal_title：Antiviral research

authors： Thibodeaux BA,Garbino NC,Liss NM,Piper J,Schlesinger JJ,Blair CD,Roehrig JT

更新日期：2012-04-01 00:00:00

abstract：:Each year, up to 10,000 cases of infections with the flavivirus tick-borne encephalitis (TBE) virus that affect the central nervous system are reported in Europe and Asia. Due to the potentially severe adverse effects of post-exposure prophylaxis with TBE virus hyperimmunoglobulin, TBE can currently only be treated sy...

journal_title：Antiviral research

authors： Achazi K,Patel P,Paliwal R,Radonić A,Niedrig M,Donoso-Mantke O

更新日期：2012-01-01 00:00:00

abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...

journal_title：Antiviral research

authors： Vanlandschoot P,Stortelers C,Beirnaert E,Ibañez LI,Schepens B,Depla E,Saelens X

更新日期：2011-12-01 00:00:00

abstract：:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infect...

journal_title：Antiviral research

authors： Laufer N,Abusamra L,Bolcic F,Gun A,Rolón MJ,Pérez H,Krolewiecki A,Salomón H,Quarleri J,Cahn P

更新日期：2011-12-01 00:00:00

abstract：:Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...

journal_title：Antiviral research

authors： Hurwitz SJ,Schinazi RF

更新日期：2011-11-01 00:00:00

abstract：:The EIAV (equine infectious anemia virus) multi-species attenuated vaccine EIAV(DLV121) successfully prevented the spread of equine infectious anemia (EIA) in China in the 1970s and provided an excellent model for the study of protective immunity to lentiviruses. In this study, we compared immune responses induced by ...

journal_title：Antiviral research

authors： Lin YZ,Shen RX,Zhu ZY,Deng XL,Cao XZ,Wang XF,Ma J,Jiang CG,Zhao LP,Lv XL,Shao YM,Zhou JH

更新日期：2011-11-01 00:00:00

abstract：:Development of efficient and safer vaccines against foot-and-mouth disease virus (FMDV) is a must. Previous results obtained in our laboratory have demonstrated that DNA vaccines encoding B and T cell epitopes from type C FMDV, efficiently controlled virus replication in mice, while they did not protect against FMDV c...

journal_title：Antiviral research

authors： Borrego B,Argilaguet JM,Pérez-Martín E,Dominguez J,Pérez-Filgueira M,Escribano JM,Sobrino F,Rodriguez F

更新日期：2011-11-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00

abstract：:The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza sub...

journal_title：Antiviral research

authors： Mancini N,Solforosi L,Clementi N,De Marco D,Clementi M,Burioni R

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The combination of tenofovir disoproxil fumarate (TDF) plus emtricitabine (FTC) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus (HBV) infection. The aim of this study was to assess the efficacy and tolerance of TDF + FTC in patients with chronic hepa...

journal_title：Antiviral research

authors： Si-Ahmed SN,Pradat P,Zoutendijk R,Buti M,Mallet V,Cruiziat C,Deterding K,Dumortier J,Bailly F,Esteban R,Wedemeyer H,Janssen HL,Zoulim F

更新日期：2011-10-01 00:00:00

abstract：:Sheeppox and goatpox, two endemic capripox infections in India, pose a significant economic threat to small ruminant productivity in the subcontinent. Vaccination of all susceptible sheep and goats is the feasible and sustainable means of control. Availability of effective live attenuated vaccines that are inherently ...

journal_title：Antiviral research

authors： Bhanuprakash V,Hosamani M,Singh RK

更新日期：2011-09-01 00:00:00

abstract：:With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combination treatments. In this study, we determined the impact of oseltamiv...

journal_title：Antiviral research

authors： Bantia S,Upshaw R,Babu YS

更新日期：2011-09-01 00:00:00

abstract：:The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3....

journal_title：Antiviral research

authors： Akuzawa K,Yamada R,Li Z,Li Y,Sadanari H,Matsubara K,Watanabe K,Koketsu M,Tuchida Y,Murayama T

更新日期：2011-09-01 00:00:00

abstract：:Anti-herpes simplex virus (HSV) activities of oxyresveratrol in vitro and topical administration in cutaneous HSV-1 infection in mice were examined. The inhibitory concentrations for 50% plaque formation (IC(50)) of oxyresveratrol against HSV-1 clinical isolates and HSV-2 clinical isolates were 20.9-29.5 and 22.2-27.5...

journal_title：Antiviral research

authors： Lipipun V,Sasivimolphan P,Yoshida Y,Daikoku T,Sritularak B,Ritthidej G,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2011-08-01 00:00:00

abstract：:Dolutegravir (S/GSK1349572) is a second-generation HIV-1 integrase inhibitor (INI) in advanced clinical development. It has shown good antiviral activity in most patients with prior raltegravir failure, although changes at the integrase codon 148, particularly when combined with other mutations, confer reduced suscept...

journal_title：Antiviral research

authors： Garrido C,Soriano V,Geretti AM,Zahonero N,Garcia S,Booth C,Gutierrez F,Viciana I,de Mendoza C

更新日期：2011-06-01 00:00:00

abstract：:Vaccination of chickens with herpesvirus of turkey (HVT) confers only partial protection against challenge with a very virulent Marek's disease virus (MDV). Here, we evaluated the ability of recombinant chicken interferon-gamma (rChIFN-γ) to enhance protective efficacy of HVT against the very virulent MDV strain, RB1B...

journal_title：Antiviral research

authors： Haq K,Elawadli I,Parvizi P,Mallick AI,Behboudi S,Sharif S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

journal_title：Antiviral research

authors： Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

更新日期：2011-03-01 00:00:00

abstract：:Oxymatrine (OMTR) is an anti-hepatitis drug used in China. Its mechanism of action is unknown. Recently, we found that OMTR inhibits hepatitis B virus (HBV) via down-regulating the expression of heat-stress cognate 70 (Hsc70), a host protein required for HBV DNA replication. Goal of this study was to assess the effect...

journal_title：Antiviral research

authors： Wang YP,Zhao W,Xue R,Zhou ZX,Liu F,Han YX,Ren G,Peng ZG,Cen S,Chen HS,Li YH,Jiang JD

更新日期：2011-03-01 00:00:00

abstract：:Certain host genetic polymorphisms in human leukocyte antigen (HLA) genes are reported to be associated with response to interferon α (IFNα) therapy. Two hundred and eighteen IFNα treatment-naïve chronic hepatitis B (CHB) patients were enrolled in the present study. HLA-A, B, C and DQA1, DQB1, DRB1 gene alleles were d...

journal_title：Antiviral research

authors： Zhu X,Du T,Wu X,Guo X,Niu N,Pan L,Xin Z,Wang L,Li Z,Li H,Liu Y

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

journal_title：Antiviral research

authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

更新日期：2011-02-01 00:00:00

abstract：:A major challenge in the development of vaccines against retroviruses is the induction of neutralizing antibodies since they prevent infection of the cells where the virus may persist. The transmembrane envelope (TM) protein contains highly conserved domains and seems to be a suitable target. To study whether vaccinat...

journal_title：Antiviral research

authors： Langhammer S,Hübner J,Jarrett O,Kurth R,Denner J

更新日期：2011-01-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotide, namely, the conversion of IMP to XMP. The depletion of the intracellular GTP and dGTP pools is the major event occurring in the cells exposed to the inhibitors such as mycophenolic acid. The prese...

journal_title：Antiviral research

authors： Khan M,Dhanwani R,Patro IK,Rao PV,Parida MM

更新日期：2011-01-01 00:00:00

abstract：:In this study we tested whether HIV-1 replication could be inhibited by stable RNAi-mediated knockdown of cellular co-factors. Cell lines capable of expressing shRNAs against 30 candidate co-factors implicated at different steps of the viral replication cycle were generated and analyzed for effects on cell viability a...

journal_title：Antiviral research

authors： Eekels JJ,Geerts D,Jeeninga RE,Berkhout B

更新日期：2011-01-01 00:00:00

abstract：:Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)...

journal_title：Antiviral research

authors： Rhee SY,Margeridon-Thermet S,Nguyen MH,Liu TF,Kagan RM,Beggel B,Verheyen J,Kaiser R,Shafer RW

更新日期：2010-12-01 00:00:00

abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

journal_title：Antiviral research

authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

更新日期：2010-12-01 00:00:00

abstract：:The aminoadamantanes, amantadine and rimantadine, have been used to prevent and treat influenza A virus infections for many years. Several reports have shown an increased level of resistance to these drugs, particularly among influenza A(H3N2) subtype viruses, during recent years. We observed an increase in amantadine...

journal_title：Antiviral research

authors： Yavarian J,Azad TM,Zheng X,Gregory V,Lin YP,Hay A

更新日期：2010-11-01 00:00:00

abstract：:Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...

journal_title：Antiviral research

authors： de Arellano ER,Alcamí J,López M,Soriano V,Holguín A

更新日期：2010-11-01 00:00:00

abstract：:Currently used antiretroviral therapy is highly successful but there is still a need for new effective and safe prophylactics and therapeutics. We have previously identified and characterized a human engineered antibody domain (eAd), m36, which exhibits potent broadly neutralizing activity against HIV-1 by targeting a...

journal_title：Antiviral research

authors： Chen W,Xiao X,Wang Y,Zhu Z,Dimitrov DS

更新日期：2010-10-01 00:00:00